实验性雏鸡汞中毒诊断指标的筛选

Selection of Diagnostic Index on Experimental Mercury Poisoning in Chickens

通过人工复制雏鸡汞中毒模型 ,筛选临床汞中毒诊断指标 ,为生产实践中防治汞中毒提供理论参考。选用健康雏鸡 1 0 0只 ,采用分组对比的方法 ,研究发病动物的临床症状、病理变化、血常规变化、肝功能变化 ,测定血液、组织和羽毛中汞含量。实验结果表明 :根据中毒动物体重明显降低 ,生长发育严重迟缓 ;实质性器官肝、肾、脑组织细胞变性坏死 ;血常规检查 RBC总数、WBC总数、Hb含量、嗜酸性 WBC减少 ;肝功能检查 GOT、GPT活性显著增高 ( P <0 .0 1 ) ,AKP活性显著降低 ( P <0 .0 1 ) ;血液、组织和羽毛中汞含量高于正常 ;结合流行病学调查 。

Reconstructed the model of mercury poisoning in chickens and selective diagnostic index were very useful for preventing mercury poisoning.One hundred 1 day old chickens were randomly divided into two groups(control group and mercury poisoning group).The clinical signs,pathological changes and results of blood examination of the chickens with mercury poisoning were studied; the mercury contents in the blood,tissue and feather were determined.The results were shown as follows:the diagnosis of mercury poisoning was established on the basis of significantly reduced bodys weight, retarded growth,necrosised cells in liver,kidney,brain and feather,the changed normal blood,increased the GOT,GPT activity(P<0.01),reduced AKP activity(P<0.01),the mercury content in the blood and tissue higher than normal level,along with epidemiological analysis.