血管内皮生长因子研究进展

The progress in research on vascular endothelial growth factor

血管内皮生长因子(Vascular Endothelial Growth Factor, VEGF)是一种由各种正常细胞或肿瘤细胞合成和分泌的糖蛋白。人类医学研究证明,VEGF有两种受体——KDR/FLK-1和FLT-1。VEGF与受体结合,具有促进血管内皮细胞的增生和提高微血管对大分子物质的通透性作用。人的VEGF 基因由8个外显子构成,主要有VEGF121、VEGF145、VEGF165、VEGF189和VEGF206等5个同型异构体。等电点的差异和肝素亲合力的差异可能是造成VEGF 生物活性差异的主要原因。

Vascular endothelial growth factor (VEGF)is a kind of protein which synthesized and secreted by a variety of normal and neoplastic cells. It is a homodimeric glycoprotein that interacts with two receptors-fms-like tyrosine kinase (Flt-1) and kinase domain-containing region (KDR ). It carries two major biological activates, one is the capacity to stimulate vascular endothelial cell proliferation and the other is the ability to increase microvessel permeability to macromolecules. To date, five human VEGF mRNA species encoding VEGF isoforms of 121,145,165,189 and 206 amino acids are produced by alternative splicing of VEGF mRNA. Previous studies demonstrated that differences in the isoelectric point and affinity for heparin may profoundly affect the biological activates of VEGF.