脑出血病人发病时间规律的研究

Study on the temporal pattern of onset of disease in patients with intracerebral hemorrhage

目的 分析脑出血病人发病时间的变化规律 ,判断不同病因脑出血病人发病的时间模式。方法 评价 819例脑出血病人发病时间的变化规律及脑出血的发生与气温变化的关系。所有病例根据病因分为 3组 :高血压性脑出血组 487例 ,继发性脑出血组 193例及原因不明性脑出血组 139例。同时评价临床因素对脑出血病人在时间分布上的影响。结果 脑出血病人常在冬季及早晨清醒状态时发病 ,在时间上均存在显著的季节性和昼夜性差异。这种差异在高血压组尤为明显 ,而非高血压性脑出血组无此差异。高血压性脑出血组中老年病人的发病时间比年青病人更具有显著的季节性。脑出血病人的发病时间没有明显的周期性变化。

Objective To analyze the temporal patterns of onset of intracerebral hemorrhage(ICH)and to determine whether or not different subgroups exhibit different patterns of onset.Methods The time variation in occurrence of ICH and the relationship between ICH occurrence and changes in air temperature were evaluated in 819 patients.The patients were divided into 3 groups according to the etiology:hypertensive ICH(487 patients),secondary ICH(193 patients),and ICH of undetermined cause(139 patients).The contribution of clinical factors to the temporal distribution of ICH was also evaluated.Results ICH in all patients often occurred in the cold months of winter and in the morning and marked seasonal and diurnal differences in ICH onset were observed.These marked differences were observed in hypertensive ICH only and not in other two groups.The seasonal pattern was more evident in elderly patients with hypertensive ICH than in young subjects.No significant weekly variation was observed.Conclusion The high incidence of ICH often occurs in the cold months and on awaking in the morning.