微小剂量卡维地洛防治大鼠急性心肌梗死左室重构的实验研究

Experimental study on efficacy of very low-dose carvedilol in preventing left ventricular remodeling after acute myocardial infarction in rats

目的 探讨微小剂量卡维地洛对大鼠急性心肌梗死 (AMI)左室重构的防治作用。方法 采用Olivetti的方法对 130只雌性SD大鼠致AMI,随机分成AMI和卡维地洛微小剂量组。另设假手术对照组。给药 4周后行血流动力学测定和病理分析。结果 AMI组与假手术组相比 ,左室舒张末压 (LVEDP)、容积 (LVV)、重量 (LVW )均显著增加(P均 <0 .0 0 1) ,左室内压最大上升和下降速率 (±dp/dp)及其校正值 (±dp/dt/LVSP)均显著降低 (P <0 .0 1～0 .0 0 1)。卡维地洛组与AMI组相比 ,LVEDP、LVV和LVW均显著降低 (P均 <0 .0 1) ,±dp/dt及±dp/dt/LVSP均显著增加 (P <0 .0 5 ～ 0 .0 1)。结论 卡维地洛微小剂量即能有效防止大鼠AMI左室重构 。

Objective To evaluate the efficacy of very low dose carvedilol in preventing left ventricular remodeling(LVRM) after acute myocardial infarction(AMI) in rats.Methods AMI model was made in 130 SD rats by the methods of Olivetti.The surviving rats were randomly assigned to AMI control and very low dose carvedilol groups.Sham operated rats were selected randomly.After Four weeks of therapy,hemodynamic studies and pathologic analysis were performed.After excluding the rats with infarct size<35% or >55%,34 rats were left,which comprised AMI(n=11), very low dose carvedilol(n=11) and Sham operated (n=12) groups.Results Compared with sham operated group,left ventricular(LV) end diastolic pressure(LVEDP),volume(LVV) and weight(LVW) were all significantly increased(all P<0.001), while LV pressure maximal rate of rise and fall(±dp/dt) as well as their corrected values(±dp/dt/LVSP) were all significantly decreased(P<0.01～0.001) in AMI group.In comparison with AMI group,the LVEDP,LVV and LVW were significantly decreased(all P<0.001), while ±dp/dt and ±dp/dt/LVSP were significantly increased(all P< 0.01) in very low dose carvedilol group,indicating that carvedilol at very low dose is effective.Conclusions Carvedilol at very low dose can prevent LV remodeling,improve hemodynamics and LV function after AMI in rats.