舟山群岛脑血管病患者血小板膜蛋白变化及临床意义

目的 为观察海岛地区脑血管病患者血小板表面GMP -140的变化情况。 方法 采用流式细胞术 ,检测了居住于舟山群岛上66例脑梗塞 ,40例脑出血及18例蛛网膜下腔出血患者急性期及恢复期血小板表面GMP -140的阳性表达率 ,并与60例健康人群进行比较。结果 脑梗塞 ,脑出血及蛛网膜下腔出血组在急性期GMP -140均高于健康对照组 ,有极显著性差异 (P<0.01) ,在恢复期上述三组GMP -140均下降 ,与急性期比较有显著性差异 (P<0.05) ,但仍高于健康人对照组 ,也有显著性差异 (P<0.05)。结论 脑梗塞 ,脑出血及蛛网膜下腔出血病人在急性期可出现血小板GMP -140升高 。

Objective To explore the change of platelet's GMP-140 in cerebrovascular disease patients in Zhoushan archipelago. Methods By FCM, the GMP-140 levels were detected in 66 cases of cerebral infarction, 40 cases of cerebral hemorrhage, 18 cases of subarachnoid hemorrhage in their acute and recover period, and compared with that of 60 normal people. Results GMP-140 levels of cerebral infarction, cerebral hemorrhage and subarachnoid hemorrhage groups were all higher than that of controls in acute period (p<0.01). The level in recovery period was lower than that of acute period (p<0.05), but still higher than control group (p<0.05). Conclusion The platelet's GMP-140 increased significantly in the acute period of cerebrovascular disease, and had dynamic relationship with the development of the disease.