光泽精在肾上腺素自氧化体系中的电化学研究

Electrochemical Behavior of the Reaction of Lucgenin with Superoxide Anion Generated by the Auto-oxidation of Epinephrine

光泽精与在肾上腺素自氧化体系中（ｐＨ＝１０．２０）产生的超氧阴离子自由基反应，其氧化产物在 －１．１６ Ｖ（ｖｓ．ＳＥＣ）和－１．６０Ｖ（ｖｓ． ＳＥＣ）处有两个还原峰，其中－１．１６ Ｖ处的还原峰是光泽精被氧化的中 间产物的双电子还原峰，－１．６０Ｖ处的还原峰是最终产物 Ｎ－甲基吖啶酮（ＮＭＡ）的双电子还原峰。形成 反应中间体和 ＮＭＡ的反应是一级反应，其反应速度常数分别为 ２．０７× １０－４ｓ－１和 ２．２３ × １０－５ｓ－１。

Lucgenin (N,N-dimethyl-9,9-biacridinium dication, I) reacts with superoxide anion generated by the auto-oxidation of epinephrine in the buffer solution of NaHCO3-Na2CO3 (pH 10.2) was studied by single sweep oscillopolarography. The reaction yielded an intermediate product [ I (OO) ] which was reduced at - 1.16 V( vs. SCE) and a fatal product ( N-methylacridone, II) which was reduced at - 1.60 V ( SCE). The first-order rate constants of I (OO) and II were 2.07 x 10(-4) s(-1) and 2.23 x 10(-5) s(-1) respectively.