以羟丙基-β-环糊精为手性选择剂的毛细管电泳法分离测定日夜百服宁片剂中的伪麻黄碱

Seperation and Determination of Pseudoephedrine in Bufferin Cold Tablet by Capillary Electrophoresis with Hydropropyl-β- Cyclodextrin as Chiral Selective Reagent

建立了伪麻黄碱手性对映体的毛细管电泳分离分析方法 ,分离用缓冲液为 2 5mmol/L的三羟甲基氨基甲烷 磷酸缓冲液 (pH 2 6 5 ) ,含 38mmol/L的羟丙基 β 环糊精。测定了日夜百服宁片剂中右旋伪麻黄碱的含量。方法简便快速 ,具有良好的精密度。

A method for the separation and analysis of the chiral pseudoephedrine enantiomers using capillary eletrophoresis was established The buffer solution for separation was 25 mmol/L Tris phosphate, including 38 mmol/L hydropropyl β cyclodextrin with pH value of 2 65. ( 1S,2S )(+) Pseudoephedrine in Bufferin Cold tablet was determined The method has good precision, recovery and linear relationship