乙基二茂铁与乙酰丙酸甲酯的缩合反应

Condensation of Ethylferrocene with Methyl Levulinate

以多聚磷酸 -浓硫酸 -甲醇为催化剂和环己烷为溶剂 ,由乙基二茂铁与乙酰丙酸甲酯缩合合成 4 ,4 -双(乙基二茂铁基 )戊酸甲酯 ,转化率 73% ,产率 84 % .正交实验法获得的适宜反应条件为 :乙基二茂铁5 5 mmol,乙酰丙酸甲酯 75 mmol,浓硫酸 3.0 m L,环己烷 2 0 m L,甲醇 1 1 m L.通过元素分析、IR、1 H NMR和1 3 C NMR确证了缩合产物的结构 .

Condensation of ethylferrocne with methyl levulinate was carried out in cyclohexane and catalyzed by PPA-H 2SO 4-CH 3OH to give methyl 4,4-bis(ethylferrocenyl) pentanate with conversion of 73% and the yield of 84%. The suitable reagent compositions obtained through orthogonal factorization method were 55 mmol ethyferrocene, 75 mmol methyl levulinate, 3 0 mL concentrated H 2SO 4, 20 mL cyclohexane and 11 mL of methanol. The structures of the compounds have been characterized by elemental analysis, IR, 1H NMR and 13 C NMR.