碳青霉烯类抗生素国外研究动态

The trend in research of carbapenem antibiotics

碳青霉烯类是新型 β 内酰胺类抗生素 ,但其结构又不同于传统的 β 内酰胺类抗生素 ,它的抗菌谱广 ,对G+菌和G-菌、需氧菌、厌氧菌都有很强的抗菌活性 ;且对 β 内酰胺酶稳定。这类抗生素可以分为 3个类型 :①对肾肽酶 I不稳定的碳青霉烯类抗生素。②对肾肽酶 I稳定 ,但不能单独使用的碳青霉烯类抗生素。③对肾肽酶 I稳定并可单独使用的碳青霉烯类抗生素。

Carbapenem is a new group of β-lactam antibiotics with a broad antibacterial spectrum and a different structure from traditional β-l actam antibiotics.Carbapenem is active against gram-positive,gram-negative,aer obic,and anaerobic bacteria and is stable to lactamases.It can be divided into type 1 carbapenem:unstable to DHP-I;type 2 carbapenem:stable to DHP-I but cann ot be used alone;and type 3 carbapenem:stable to DHP-I and can be used alone.