灯盏花素注射液对不稳定型心绞痛患者内皮细胞保护作用的观察

Observations on Protective Actions of Breviscapini Injection on Endothelial Cells of Patients with Unstable Angina

目的 :观察灯盏花素注射液对不稳定型心绞痛 (UP)患者内皮细胞的保护作用。方法 :将 6 0例 UP患者随机分为常规组和治疗组 ,治疗组在常规组治疗基础上加用灯盏花素注射液。观察治疗前后 2组患者血中各指标的变化。结果 :治疗后 ,2组患者血栓素 A2 (TXA2 )水平明显降低 ,6酮前列腺素 F1α(6 keto PGF1α)水平明显增高 (P均 <0 .0 1) ,但治疗组变化程度大于常规组 (P均 <0 .0 1) ;治疗组脂质过氧化物 (L PO)、遗传性假血友病第 因子 (v WF)和纤维结合蛋白 (Fn)水平均降低 ,超氧化物歧化酶 (SOD)水平增高 (P均 <0 .0 1) ,常规组 L PO、SOD、v WF和 Fn则无显著变化 (P均 >0 .0 5 )。治疗前 U P患者 L PO与 v WF呈直线相关 (r=0 .5 2 ,P<0 .0 1) ,治疗后 L PO与 v WF降低值呈直线相关 (r=0 .71,P<0 .0 1)。结论 :灯盏花素注射液具有抗脂质过氧化反应 ,调整血栓素 A2 /前列环素 I2 (TXA2 / PGI2 )比例平衡 。

OBJECTIVE:To observe the protective actions of Breviscapini Injection on endothelial cells of patients with unstable angina (UP),METHODS:60 cases with UP were randomly divided into convention and treatment group. Breviscapini Injection was added to treatment group based on conventional therapy. The variations in many blood parameters were observed before and after therapy.RESULTS:After therapy the concentrations of theromboxin A 2(TXA 2)markedly lowered and 6 ketoprostanglandin F 1α(6ketoPGF 1α ) markedly increased(P<0.01)in both two groups.However the extent of variation in treatment group was larger than that in convention group(all P<0.01).All the concentrations of lipid peroxidation(LPO),von Willebrand factor (vWF) and fibronectin(Fn)lowered, meanwhile the concentration of super oxide dismutase(SOD)increase(all P<0.01) in treatment group. There were no obviously variations in the concentrations of LPO,SOD,vWF and Fn(all P>0.05) in convention group. Before therapy a direct linear correlation(r=0.52,P<0.01) between LPO and vWF was shown for patients with UP. After therapy, the decreased values of LPO and vWF showed a direct linear correlation(r=0.71, P<0.01).CONCLUSION:The Breviscapini Injection possesses the actions on antagonizing lipid peroxide reaction, regulating proportional balance of theromboxin A 2(TXA 2) and prostaglandin I 2(PGI 2),protecting endothelial cells of vessels, and promoting repair of injured vasoendothelial cells.