一种简单、精确计算EC_(50)的方法

A Simple and Accurate Method for Calculation of the EC_(50)

提出了一种计算药物量 -效曲线参数半数效量 ( EC50 )的新方法 ,可精确计算落在两已知浓度间的 EC50 ,不需绘图测算或计算机曲线拟合。该方法比常用的绘图计算的方法更加快速、精确和简单 ,能广泛应用于药效动力学研究。

A new method for the calculation of EC50 of drug concentration-effect curves is presented. It may avoid the necessity for graph construction or computational curve-fitting programs and allows accurate calculation of the EC50 where the value falls between two known concentrations. The new technique is faster, more accurate, and simpler to perform than graph technique used for the calculation of the EC50 and can be widely applied to many other pharmacodynamic investigation.