抗纤Ⅰ号胶囊对肝纤维化大鼠作用的实验研究

Experimental Study of KANGXIAN-Ⅰ Capsule on Hepatic Fibrosis Rats

观察抗纤 号胶囊对实验性肝纤维化大鼠血清 LN、PC 、 -C、HA、肝功能和肝组织病理变化的作用。结果 :治疗组层粘连蛋白 ( LN)、 型前胶原明显降低 ,白蛋白明显升高 ,与秋水仙碱对照组比较有显著性差异 ;肝细胞变性、坏死比对照组明显减轻 ,肝纤维化程度也明显轻于对照组。结论 :抗纤 号胶囊抗肝纤维化作用肯定 ,其机理之一 ,可能是通过降低 LN、PC ,从而消除肝窦毛细血管化 ,调节肝脏微循环 ,达到抗肝损伤 。

The effects of KANGXIAN Ⅰ capsule on serum laminin(LN),procollagen 3(PCⅢ),collagen Ⅳ(Ⅳ C),hyaluronic acid(HA),hepatic function and pathological changes of liver tissue in hepatic fibrosis rats were observed.The results showed that the values of LN and PCⅢ were obviously decreased,while the values of albumin were increased in observation group,and there was significantly different in comparison with crocus alkali control group.The cell degeneration and necrosis,as well as the degree of hepatic fibrosis were obviously superior to that in the control group.It concludes that KANGXIAN Ⅰ capsule has anti fibrosis effects,and its pathogenesis is likely to inhibit hepatic injuries and recover its functions by the way of reducing LN and PCⅢ,eliminating liver sinusoidal capillarization,and adjusting liver microcirculation.\;