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智脑胶囊对白细胞介素1诱导大鼠脑组织APP mRNA表达的影响 被引量:4

EFFECT OF ZHINAO GAPSULE ON EXPRESSION OF AMYLOID PRECURSOR PROTEIN mRNA IN BRAIN TISSUE OF RAT INDUCED BY INTERLEUKIN-1β
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摘要 目的 :探讨具有健脾补肾、益气养阴、豁痰祛瘀、开窍健脑功用的智脑胶囊治疗Alzheimer病的作用机理。方法 :采用Northern杂交 ,放射自显影等方法观察了智脑胶囊对白细胞介素I(IL - 1)诱导大鼠脑组织 β 淀粉蛋白前体蛋白 (APP)mRNA表达的影响。结果 :智脑胶囊能下调IL - 1诱导的大鼠脑组织APPmRNA过表达 ,结论 :智脑胶囊可通过作用于β AP的前体蛋白环节而减少 β AP在脑组织内沉积来对AD的病情进行有效干预 。 Objective:To explore the mechanism of Zhinao capsule(a compounded herbal medicine with the function of invegorating the spleen and tonifying the kidney,supplementing qi and nourishing yin ,eliminating phlegm and removing blood stasis,And causing resuscitaion and strengthening the brain)on Alzheimer's disease(AD).Methods:Northern blot and autoradiography etc were used to observe the effect of Zhinao capsule on the expression of amyloid precursor protein mRNA(APPmRNA) of brain tissue of rats induced by interleukin-1β(IL-1β).Result: Zhinao capsule could downregulate the overexpression of APPmRNA of brain tissue of rats induced by IL-1β. Conclusions: Zhinao capsule can reduce the deposits of β-amyloid protein(β-AP)and treat the AD by APP channel,which is a new pharmacological evidence of Zhinao capsule treating AD.
出处 《中国中医药科技》 CAS 2001年第6期375-376,共2页 Chinese Journal of Traditional Medical Science and Technology
基金 安徽省自然科学基金项目NO .990 4 4 5 91
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