急性脑缺血患者血浆NSE水平动态观察意义

The significance on dynamic change of NSE in the blood plasma of patients with acute ischemic stroke

目的 研究缺血性脑卒中患者血浆神经元特异性烯醇酶 (Neuron specificenolase ,NSE)的变化及与预后的关系。 方法 病例组 5 0例 ,正常对照组 30例。患者分别于入院 2 4小时内 ,第 2天至第7天连续采集血标本。血浆NSE测定采用酶联免疫分析方法 ,神经功能缺损评定按斯堪的纳维亚卒中量表 (SSS)标准进行。 结果 病例组 3天内血浆NSE明显高于对照组 (P <0 0 1)。NSE的变化是一个动态变化过程 ,预后恶化组血浆NSE 7天后仍明显高于预后良好组 (P <0 0 1)。 结论 脑缺血早期NSE血浆明显升高 ,NSE的动态变化反映了缺血后神经元的损伤是一个动态变化过程。 7～

Objective To investigate the dynamic change of NSE of blood plasma in patients with acute cerebral infarction and know its significance for prognosis Methods The concentration of NSE in blood plasma of 50 patients with acute cerebral infarction was examined and analyzed in different days (after admission 1st,2nd 3rd 4th ......7th day) Results The plasma level of NSE in patients with acute cerebral infarction was increased at the 1st day,3rd,5th and 7th day respectively Conclusion The dynamic change of NSE in acute cerebral infarction suggested it might reflect the brain injury