肽缀合反义寡核苷酸的合成和性能

Synthesis and Properties of Peptide-oligonucleotide Conjugates

反义寡核苷酸可作为基因表达的抑制剂和潜在的治疗药物 ,但多种类型的寡核苷酸为聚阴离子化合物 ,难以跨过细胞膜 .已知包括融合肽、信号肽在内的多种生物活性多肽具有跨膜与核定位能力 .讨论了反义寡核苷酸

Antisense-oligonucleotide can be employed as gene expression inhibibor and potential therapeutic agents. However, many classes of oligonucleotide are polyanion and cannot penetrate cell membrane. It is known that several peptides, including fusion peptide and signal peptide, have the properties of transmembrane and/or cell nucleus localization. The synthesis and biological activity of antisense oligonucleotide-peptide conjugates are discussed.