摘要
转录因子圈套策略 (transcriptionfactor“decoy”strategy)是应用与顺式元件相一致的寡核苷酸双链转染细胞 ,竞争结合转录因子 ,从而抑制内源性基因表达 .
The transcription factor 'decoy' strategy had been reported that applying double-strands oligodeoxynucleotides (ODNs) transfect target cells and compete with the sequence of endogenous cis-element for binding to transcription factor, thus leading to prevention of the endogenous gene expression. 'Decoy' strategy was not only a novel strategy for gene therapy but also a powerful tool for the study endogenous gene regulation.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2001年第6期802-805,共4页
Progress In Biochemistry and Biophysics
基金
国家重点基础研究发展规划项目 (973) (G1 9990 542 )
国家自然科学基金资助项目 (30 0 80 0 0 9)~~
关键词
圈套策略
转录因子
基因治疗
基因调控
'decoy' strategy
transcription factor
gene therapy
gene regulation
