精原细胞移植研究的进展

Progress in the Study of Spermatogonial Transplantation

自 1994年Brinster实验室首次成功地进行了精原细胞移植以来 ,近年来在这一领域进行的一系列研究又取得了不少新的重要发现 ,生精细胞不但可以在同一种属的不同动物间进行移植 ,还可以在不同种属的动物间进行移植 .这对雄性生殖研究 ,尤其是对睾丸内支持细胞与生精细胞之间相互作用的研究是一项重大的技术突破 .实质上 。

Since the first report of successful spermatogonial transplantation issued by Brinster's laboratory in 1994, some important new findings has been revealed by a series of recently studies relating to spermatogonial transplantation. It has been found that germ cell can be transferred not only from one animal to another, but also from one species to another, which is a big technological breakthrough in the male reproductive researches, especially for the study of Sertoli-germ cell interaction. In essence, Brinster's laboratory has pioneered another transgenic technology that is capable of modifying the entire genome of the animal.