红细胞在钙离子和离子载体A23187作用下的流变特性研究

Rheology Characteristics of Erythrocytes Under the Influence of Calcium Ions and Ionophore A23187

用新激光衍射法研究了钙离子及离子载体A2 3187对红细胞流变特性的影响 .用不同浓度的钙离子及离子载体A2 3187分别处理红细胞后 ,测量其取向指数和小变形指数 .结果表明离子载体A2 3187较细胞外钙离子浓度对红细胞流变特性的影响更大 .而且 ,最大取向指数和最大小变形指数随着钙离子及离子载体A2 3187浓度的增加而降低 .离子载体A2

In order to study effect of extracellular Ca2+ and ionophore A23187 on erythrocyte deformation, the new ektacytometry is used. After erythrocytes were treated with different concentrations of intercellular Ca2+ and ionophore A23187 respectively, the orientation index ( DI)(or) and small deformation index ( DI)(d) of the erythrocytes were measured. It is suggested that the effect of ionophore A23187 on the rheology of erythrocytes is more notable than that of intercellular Ca2+. Furthermore, the ( DI)(or,max) and ( DI)(d,max) decrease as the concentration of intercellular Ca2+ or ionophore A23187 is increased. The deformability of erythrocytes was obviously reduced after treated with ionophore A23187.