摘要
光镊是对生物样品的力学特性进行研究的方便工具 .红细胞膜弹性是血液的生理功能指标 .利用单光镊技术我们建立了测量红细胞膜弹性的新方法 .利用该方法对红细胞的膜弹性进行测量 ,该结果与国外文献报道的双光镊法测量结果相一致 .对不同浓度氧化苯砷 (PAO)处理的红细胞膜弹性进行了测量 ,测量结果表现出浓度与膜弹性之间有明显的线性关系 。
The optical tweezers are convenient tools for investigation of mechanical characteristic of biological particle. The elasticity of red cell membrane is an important index for people to appraise the ability of blood transporting oxygen. Using single optical tweezers technology, a new method to measure the elasticity of RBC membrane was established. Adopting this new method, the elasticity of normal RBC membrane was detected and were consistent with the results of double optical tweezers method. Moreover, the membrane elasticity for RBC with phenylarsine oxide (PAO) was measured. The result displayed a linear relationship between elasticity decrease and increase of PAO concentration. Therefore, this new method has high sensitivity and is acceptable.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2001年第6期904-907,共4页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金资助项目 (1 9890 380 )~~
关键词
单光镊
红细胞
膜弹性
氧化苯砷
PAO
optical tweezers
red cell
membrane elasticity
phenylarsine oxide
