MICA基因微卫星多态在中国13个群体中的分布

Distribution of MICA Microsatellite in 13 Population Groups of China

通过对中国 1 3个群体 (云南汉族、广东汉族、山东汉族、白族、傣族、拉族、黎族、纳西族、撒拉族、畲族、土族、佤族和云南藏族 )共 5 77例无亲缘关系的研究对象的DNA样本进行MICA基因微卫星扫描分型 ,获得了该微卫星的不同等位基因在各群体中的遗传数据。结果表明 ,该微卫星在不同群体中的分布存在差异 ,并有较高的多态信息含量 (PIC) ,是一个有用的遗传标记 ,在人类进化研究、个体识别、亲子鉴定。

The genetic data of MICA microsatellite were obtained by genotyping 577 samples in 13 population groups of China,which are Han YN,Han GD,Han SD,Bai,Dai,Lahu,Li,Naxi,Sala,She,Tu,Wa and Zang YN,with genescan. Five alleles have been observed in the population groups,which are A4,A5,A5.1,A6 and A9. A5 allele is the most frequent in all population groups except Lahu and Li,while the most frequent allele for Lahu and Li is A5.1 and A4 respectively. The second most frequent allele is the A5.1 in Han YN,Han SD,Dai,Naxi,Sala,She,and Wa. The lest frequent allele for Han YN,Han GD,Lahu,Naxi,She,Wa is the A6 which is not observed in Li. A4 allele is the lest frequent in Han SD,Bai,Dai,Sala,Tu,Zang YN. The results show that the distribution of MICA microsatellite is different in these population groups,and the polymorphism information contents ( PIC ) of this microsatellite is high. It is a potential useful marker in the study of human origin and migration,personal identification,gene mapping and location,and disease diagnosis.