小鼠脑内甘氨酸含量在缺氧预适应中的变化(英文)

Changes in glycine content in mouse brain during hypoxic preconditioning

在小鼠重复缺氧预适应过程中 ,用HPLC方法 ,测定其全脑与不同脑区中的甘氨酸含量。结果表明 ,随着动物对低氧耐受性的增高 ,其全脑、间脑 ,特别是海马、脑干中的甘氨酸含量升高。结果提示 。

Glycine content of the whole brain and subregions was measured by high pressure liquid chromatography (HPLC) in mice during their repetitive exposures to hypoxia. The contents of glycine in whole brain, diencephalon, and hippocampus and brain stem was significantly increased as the animals′ tolerance to hypoxia was increased. The results suggest that glycine, as an inhibitory neurotransmitter in the brain, may positively contribute to the development of hypoxic preconditioning.