期刊文献+

检测血清肌钙蛋白诊断急性病毒性心肌炎 被引量:5

Determination of Cardiac Troponins to Diagnose Inflammatory Heart Disease
下载PDF
导出
摘要 目的比较血清心肌肌钙蛋白与血清CK -MB水平诊断心肌炎性损伤的敏感性和特异性。 方法建立急性病毒性心肌炎小鼠模型 ,测定小鼠血清心肌肌钙蛋白I(cTnI)、心肌肌钙蛋白T(cTnI)及肌酸激酶MB同工酶(CK -MB)水平 ;同时观察 42例临床拟诊急性病毒性心肌炎患者血清肌钙蛋白及血清CK -MB水平。 结果 2 8只病鼠中 19例 (6 7.85 % )cTnI升高 ,17例 (6 0 .71% )cTnI升高 ,6例 (2 1.42 % )CK -MB升高 ;42例患者中 2 6例 (6 1.9% )cT nI升高 ,16例 (38.1% )cTnT升高 ,2例 (4 .76 % )CK -MB升高。 结论测定血清肌钙蛋白水平探查心肌炎性损伤远较血清CK Objective To investigate systematically whether cardiac troponin I and T and CK-MB are useful for the diagnosis of inflammatory heart disease. Methods A murine models of acute viral myocarditis were established. cTnI and cTnT were first measured in these mice. On the basis of animal experiments, we proceeded to measure the markers in the sera from 42 patients with acute myocarditis. Results Among the 28 mice and 42 patients with myocarditis, 19 mice and 26 patients were found to have elevated cTnI values, 17 mice and 16 patients had elevated cTnT values, but CK-MB values were only elevated in 6 mice and 2 patients. Thus, the frequency of a positive cardiac troponin level was significantly greater than a positive CK-MB value to diagnose inflammatory heart disease (P<0.02). Conclusion cTnI and cTnT were superior to CK-MB for the detection of myocyte injury in myocarditis.
出处 《上海第二医科大学学报》 CSCD 2001年第4期338-340,共3页 Acta Universitatis Medicinalis Secondae Shanghai
  • 引文网络
  • 相关文献

参考文献2

  • 1杨英珍,病毒性心肌炎,1991年,29页
  • 2Cummins P,Eur J Clin Invest,1987年,17卷,317页

同被引文献34

  • 1李宗福.急性病毒性心肌炎患儿血清CTnI、IL-8测定的临床意义[J].临床输血与检验,2011,13(2):126-127. 被引量:1
  • 2赵美华 陆秋芬 等.血清心肌肌钙蛋白I对急性病毒性心肌炎的诊断价值[J].中华心血管病杂志,1999,27(2):158-158.
  • 3胡大一 黄元铸.急性冠脉综合征(第1版)[M].北京:人民卫生出版社,2001.48-70.
  • 4吴铁吉.病毒性心肌诊断标准(修订草案).中华儿科杂志,2000,38(2):755-755.
  • 5Lang K, Borner A , Figulla HR. Comparison of biochemical markersfor the detection of minimal myocardial injury :superior sensitivity ofcardiac troponin-T ELISA. J Intern Med ,2000 ,247 (1) :119-123
  • 6Anne MM , Lawrance J , Harold F , et al. Molecular cloning of rat cardiac troponin I and analysis of troponin I isoform expression in developing rat heart Biochem ,1991,30:707-709
  • 7Karjalainen J , Heikkila J. Incidence of three presentations of acute myocarditis in young men in military service, i 2 year experience. Eur Heart J, 1999,20 (15):1120-1125
  • 8Antman EM, Tanasijevic MJ, Thompson B ,et al. Cardiacspecifictroponin I levels to predict the risk of mortalily in patients with acute coronary syndromes.N Eng J Med ,1996,335 (7) :1342-1349
  • 9王新元,祝峰.MODULAR模块式一体化分析仪常见报警及排除[J].现代检验医学杂志,2007,22(5):30-31. 被引量:5
  • 10Hmnn C W, Katus H A. New biochemical markers for myocar- dial cell injury[J]. Current Opinion, 1995, 10(3) : 335-342.

引证文献5

二级引证文献14

;
使用帮助 返回顶部