多发性脑梗塞对大鼠学习记忆的影响及9601方的防治作用

Protective and Curative Effects of the TCM Formula 9601 on Learning Disorder and Dysmnesia Resulted from Multiple Cerebral Infarction

在建立多发性脑梗塞学习记忆障碍大鼠模型的基础上 ,通过跳台、避暗和水迷津实验方法研究脑梗塞缺血对大鼠学习记忆的影响及中药的防治保护作用。结果表明 :微栓子致多发性脑梗塞可明显造成大鼠学习记忆障碍的行为学改变 ,960 1方可以改善和提高造模大鼠的学习记忆能力 ,尤其是造模前给药可明显改善记忆保持力。

The influence of multiple cerebral infarction on learning and memory, and the protective and curative effects of the TCM formula 9601 on learning disorder and dysmnesia, were studied in the rat model of learning disorder and dysmnesia resulted from multiple cerebral infarction by step_through test, step_down avoidance test and water maze task performance. The results showed that multiple cerebral infarction caused by microemboli could markedly change the behavior of the model rats and cause learning disorder and dysmnesia in them, and the TCM formula 9601 could improve and increase the learning ability and memory of the model rats. The results also showed that the administration of the TCM formula 9601 to the rats before the inducing of multiple cerebral infarction, could remarkably increase the retention of memory, which provides experimental data for the application of the TCM formula 9601 in the prevention and treatment of vascular dementia.