小肠与膀胱粘膜对同一致癌尿液环境反应的实验研究

Study on different responses of rats′ small intestine mucous membrane and bladder transitional epithelium in the same carcinogenic urine environment

目的 初步验证小肠粘膜置换膀胱移行上皮预防膀胱癌复发的理论依据。方法 作者将 17只大白鼠行小肠段移植于膀胱 ,手术后与 11只对照组大白鼠共同用N 丁基 N 4 羟基丁基亚硝胺 (BBN)进行诱发肿瘤的实验 ,并将实验结果结合有关文献作了分析研究。结果 (1)除一只大白鼠外 ,所有移植到膀胱上的小肠 ,均未发生肿瘤。 (2 )所有对照大白鼠膀胱粘膜均有肿瘤发生。结论(1)由BBN诱发膀胱肿瘤的大鼠尿液所含致癌物质可能只对特定的靶组织—膀胱移行上皮有致癌作用 ,而对小肠上皮无致癌作用。 (2 )移行上皮本身可能对尿中致癌物质敏感 ,比小肠上皮容易发生癌变 ,其机制值得进一步深入研究。

Objective To preliminarily verify the tentative idea of replacement of bladder transitional epithelium with small intestine mucous membrane to prevent recurrence of carcinoma of bladder. Methods A certain segment of small intestine was transplanted to the urinary bladder of the same body in 17 rats. Then N butyl N (4 hydroxy butyl) nitrosamine (BBN) was used to induce carcinoma of bladder. BBN was used to 11 control rats that did not undergo operation. Results Bladder carcinoma failed to be found in the transplanted small intestine mucous membrane in all experimental rats except one. After stimulation of BBN, carcinoma of urinary bladder occurred in all rats′bladder transitional epithelium. Conclusion 1) The carcinogenic substances in the urine of rats suffering from BBN induced bladder carcinoma are carcinogenic only to bladder transitional epithelium and have no effect on small intestine epithelium. 2) Bladder transitional epithelium may be more sensitive to the urine carcinogenic substances and easier to be cancerized than small intestine epithelium. 3) The tentative idea of substitution of small intestine mucous membrane for bladder transitional epithelium to prevent the recurrence of bladder carcinoma is worth further studying.