沂蒙山区孕妇血液与新生儿脐血中TSH水平的相关分析

CORRELATION ANALYSIS OF TSH CONTENT IN THE BLOOD OF PREGNANT WOMEN AND NEONATES IN YIMENG MOUNTAIN AREA

目的 观察沂蒙山区正常孕妇不同孕期血液与新生儿脐血中的促甲状腺激素 (TSH )的关系 ,及其用于碘缺乏状态的判断意义。方法 利用免疫放射分析方法 ,对 30 0例正常孕妇孕前期、孕早期、孕中期、临产时血液和新生儿脐血中TSH进行检测和相关性分析。结果 新生儿脐血中的TSH值轻度增高 ,男女新生儿脐血中的TSH无显著性差异。妇女妊娠后血液中TSH值较孕前明显增高 (P <0 .0 5 ) ,不同孕期血液中TSH水平与新生儿脐血中TSH值存在明显的正相关关系 ,以孕早期和孕中期最为显著 (P <0 .0 1)。结论 检测新生儿脐血中TSH值 ,可以用于判断新生儿碘营养状态 ;监测孕期母体血液中TSH水平 ,可以评估胎儿的碘营养水平 ,指导孕妇科学补碘 ,对预防胎儿和新生儿碘缺乏具有重要意义。

ObjectiveTo explore the correlation between the contents of thyroid-stimulating hormone (TSH) in the blood of pregnant women and neonates in Yimeng Mountain Area and the value of applying the correlation to the judgement of iodine.Methods TSH determination and the correlation analysis were made in 300 cases of normal pregnant women in their pregestation,premature phase,metaphase and parturient phase and their children.Results The TSH values increased slightly in neonates compared with those in their mothers,but no obvious differences were found between male and female neonates.The TSH value increased markedly after pregnancy(P<0.05).Positive correlation was found between the TSH values of neonates and their mother,especially in the premature phase and metaphase(P<0.01).Conclusion TSH assaying can be used to judge the iodine nutrition state in neonates.TSH monitoring of the maternal blood can be used to assay the iodine nutrition value and be used to instruct pregnant women to supplement iodine so as to prevent iodine deficiency in fetuses and neonates.