中老年男子部分性雄激素缺乏临床观察——106例安雄补充疗法

TESOSTERONE(ANDRIOL )REPLACEMENT THERAPY IN 106CASES OF PADAM

目的观察十一酸睾酮能否改善老年男子部分性雄激素缺乏(PADAM)症状。方法每日口服60mg安雄6～12个月以上,治疗前后检测血清孕激素、雌激素、雄激素、PSA及fPSA。采用国际通用PADMS量表自我评定。资料用卡方做统计学处理。结果除性兴趣之外,体能及心理、心血管、精神症状均有显著改善(P<0.01)。血清睾丸酮较前升高者点38.8%。结论长期口服小剂量60mg/日安雄能提高老年男子生活质量,而且安全。

Objective To observe whether testosterone imp roves PADAM Symptoms.Methods Oral Andriol 60mg /daily was given for over 6～12months.Before and after treatment,serum estroge n,progestins,testosterone,PSA an d fPSA were de-termined.Self Rating Scale used by P sychology Department of Bosphorus Universiy,Istanbul was adopted.Results The overall PADAM Scores were singnificantly im proved(P<0.01)except sexual interest .Serum testo sterone level increased about 38.8%(P<0.001).No change of PSA and fPSA serum levels had been observed.Conclusions In aged men,treatment with Andriol for 6～12months or even longer significantly improved the life quality wi th safety.[