心肺复苏过程中血清白介素8(IL-8)、内皮素(ET)、心房肽(ANP)水平的研究

The Research of Serum IL-8、ET and ANP's Alteration During The Process of CPR

目的:探讨心跳骤停、心肺复苏过程中血清白介素8(IL-8)、内皮素(EP)、心房肽(ANP)水平的变化。方法:取心跳骤停、经心肺复苏抢救后患者34例(恢复自主循环24例,未恢复自主循环10例)和10例正常健康人作对照研究。用酶免吸附试验、放免测血清IL-8、EP、ANP。结果:自主循环恢复后,IL-8明显增高,而EP和ANP水平明显降低。结论:心跳骤停、心肺复苏过程活性物质及细胞因子发生显著改变,IL-8增高可能是复苏成功的一项指标,而EP和ANP水平增高可能是预后不良的指标。

Purpose:To investigate the alteration of serum IL-8, ET, ANP, we examined the changes of serum IL-8, ET, ANP after cardiac arrest. Method:34 cardiac arrest patients were classifed into two groups, those who achived return of spantaneous circulation (ROSC)( n =24) and those without ROSC( n = 10): 10 normal healthy volunteers served as control subject. We measure serum IL-8, ET, ANP by ELISA or RIA.Results: In patients with ROSC cardiac arrest and CPR led to increase in level of serum IL-8 or decrease in level of serum ET and ANP. Conclusion: Cardiac arrest and CPR led to alteration of vasaular active substance and cytokine, serum IL-8 increased is benefical to ROSC, serum EET and ANP increased might help to identify patients at higher risk for adverse outcome.