摘要
目的 评估雷米普利对各种适应症的效果和安全性,为医院药品购进和管理、临床医生用药提供研究依据,并探讨基于证据进行药物评估的实用方法。方法 采用系统评价和卫生技术评估原则,检索Medline,Cochrane Library及药业公司提供有关资料,全面收集全世界范围内发表的有关雷米普利(Ramipril)的研究文章,对纳入研究逐个进行质量评价,并将所有研究结果进行综合分析。结果 收集到214篇提到雷米普利的文章,符合纳入标准的共18篇,病例数共计31139例。研究内容包括:高血压、糖尿病、心衰、心肌梗塞、肾病、心脑血管病的二级预防。结论 根据现有证据,我们认为此药是一种有效、安全、易使用的药物,值得推广应用。
Objective To assess the effectiveness and safety of one kind of ACEI--Ramipril, for providng proofs forclinical implement and we also tried to explore the practical method of evidence-based drug assessment. Method By using the methods and principles of systematic review (SR),and health technology assessment (HTA).we searched Medline and Cochrane Library, together with related materials provided by pharmaceutics and collected all the published clinical research reports on Ramipril. Based on principles of SR and HTA, we assessed all the included reports comprehensively. Results We totally collected 214 articles about Ramipril, in which there were 18 articles meeting the inclusion criteria and 31 139 patients were enrolled in these studies. The research contents include; hypertension, diabetes mellitus, heart failure, myocardial infarction, nephropathy and secondary prevention for cardio-cerebral vascular disease. Conclusion According to our clinical evidence assessment, Ramipril is an effective, safe and easy to take drug and is worthy to spread.
