急性脑梗塞患者血浆一氧化氮的动态变化

目的 探讨一氧化氮 (NO)在急性脑梗塞中的演变过程及其临床意义。方法 检测急性脑梗塞患者病程第1、2、3、7、14天血浆一氧化氮浓度。结果 55名患者血浆一氧化氮浓度持续升高可延至病程的第二周末 (P<0.01) ,高峰出现在病程的1-2天。NO水平的高低与梗塞范围的大小、神经功能损害程度有密切关系。结论 急性脑梗塞患者血浆一氧化氮水平升高 ,随时间推移逐渐下降 ,NO可作为脑梗塞患者病情判断的一个指标 。

Objective To explore the dynamic changes and clinical value of serum NO level in acute cerebral infarction cases. Methods Detection of serum NO was made on the 1st, 2nd, 3rd, 7th and 14th day of the onset of acute cerebral infarction. Results The serum NO remained the high level until the end of the 2nd week (P<0.01). The highest NO level appeared on the 1st and 2nd day of the disease. Significant correlation was observed between NO level and infarction size and nerve damage. Conclusion Serum No level could serve as an index for the prognosis of acute cerebral infarction and provide the basis for the treatment.