硫氮酮对心肌梗塞患者左室舒张和充盈动力学的急性效应

ACUTE EFFECT OF DILTIAZEM ON LEFT VENTRICULAR RELAXATION AND FILLING DYNAMICS IN PATIENTS WITH MYOCARDIAL INFARCTION

应用脉冲多普勒评价一次口服硫氮(艹卓)酮90mg对心肌梗塞患者左室舒张和充盈动力学的急性效应。结果表明,服药后左室舒张早期最大流速、E/A比值、快速充盈分数和快速充盈减速度分别增加10.8%±3.3%(P<0.01),20%±6.5%(P<0.O1),17%±4.8%(P<0.001)和19.8%±9.9%(P<0.01),等容舒张期缩短10.4%±4.7%(P<0.001)。提示心肌梗塞后左室舒张和充盈功能失常在一定程度上是可逆的,硫氮(艹卓)酮能有效地改善心肌梗塞患者的左室舒张和充盈功能。

Doppler echocardiography was used to evaluate the acute effects of oral diltiazem, 90mg, on left ventricular diastolic function in 30 patients with myo- cardial infarction. The results showed that diltiazem favorably induced changes in Doppler indices of abnormal diastolic function. Peak early velocity, E/A ratio, early diastolic filling fraction and early diastolic filling deceleration increased by 10.8%±3.3% (P<0.01), 20%±6.5% (P<0.01), 17%±4.8% (P<0.001) and 19.8%±9.9% (P<0.01), respectively after single dose of diltiazem. Isovolumic relaxation time decreased by 10.4%±4.7% (P<0.001). Thus, the diastolic abnormality in patients with myocardial infarction was rever- sible to some extent, and diltiazem could enhance relaxation and increase the filling in early diastole effectively, indicating an improved left ventricular diastolic performance.