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大鼠室旁核神经元对胃充胀及静脉注射胆囊收缩素的放电反应 被引量:2

RESPONSE OF NEURONS IN RAT PARAVENTRIULAR NUCLEUS TO GASTRIC DISTENSION AND INTRAVENEOUS INJECTI0N OF CHOLECYSTOKININ OCTAPEPTIDE
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摘要 对大鼠室旁核(PVN)神经元静脉注射胆囊收缩素(CCK-3)及胃充胀的电活动变化进行了观察。结果表明,静脉注射CCK-8及胃充胀可使室旁核内血压不敏感细胞电活动加强,而血压敏感细胞不出现兴奋反应。提示室旁核与胃之间的神经联系可能在摄食行为的调节中起重要作用。 The effect of intravenous administration of cholecystokinin octapeptide (CCK-8) and gastric distention on the electric activity of the paraventricular nucleus (PVN) in rats was studied. The electric discharges of the cells insensitive to baroreceptor activation could be increased by intravenous administration of CCK-8 and gastric distension. This increase was not observed in cells sensitive to baroreceptor activation. The nervous connection between PVN and the stomach may play an important role in food intake regulation.
作者 唐明 王学勇
出处 《青岛医学院学报》 1991年第3期173-176,共4页 Acta Academiae Medicinae Qingdao Universitatis
关键词 下丘脑 CCK PVN 胆囊收缩素 电活性 cholecystokinin stomach distension hypothalamus, anterior electric activity rats, inbred strains
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  • 1Crawley JN, Corwin RL. Biological actions of cholecystokinin[J].Peptide, 1994,15(4):731
  • 2Jenkins JS, Nussey SS. The role of oxytocin:Present concept[J].Clinical Endocrinology,1991:34:515
  • 3Verbalis JG, McCann MJ, McHale CM. Oxytocin secretion in response to cholecy-stokinin and food intake: different mediation of nausea from satiety[J].Science,1986,232:1417
  • 4Renaud LP, Tang M,McCann MJ. Cholecystokinin and gastric distension activate oxytocinergic cells in rat hypothalamus[J].Am J Physiol, 1987,253:661

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