子宫颈腺癌组织中雌激素和孕激素受体的研究

A STUDY OF ER AND PR IN ADENOCARCINOMA OF THE UTERINE CERVIX

采用免疫金银染色技术,对64例子宫颈腺癌组织进行了雌激素受体(ER)、孕激素受体(PR)的免疫组化检测。结果表明,ER和PR的阳性率分别为59.38%和50.00%。二者阳性率在不同的分化程度间均有显著差别(P<0.05);不同组织学类型间,ER阳性率有显著性差别(P<0.05),PR差别则不显著(P>0.05)。二者阳性率在绝经前后,两组间差别亦无显著性(P>0.05)。两种受体阳性间存在着正相关关系(P<0.005,r=0.4454)。提出对受体阳性者可以进行激素治疗。

The detection of the estrogen receptor (ER) and progesterone receptor (PR) was carried out in 64 cases of cervical adenocarcinoma by means of the immunogold-silver staining technique. The positive rates for ER and PR were 59.38% and 50.00% respectively. The positive rates of both varied significantly with the degree of differentiation of the tumor tissue. Among the different histological types, there were significant variations in the positive rate of ER (P<0.05), but not in that of PR. No significant differences were found in positive rate between the pro-and post-menopausal age groups (P>0.05). There existed a positive correlation between the positive rates of ER and of PR (P<0.005, r= 0.4454). The authors consider that for the receptor positive patients there is a possibility of therapeutic tests with sex hormone.