氯胺酮对体外循环病人IL-6和IL-8的影响及其意义

Effects of katamine on cardiopulmonary bypass-induced interleukin-6 and interleukin-8 response and its significance

目的 :观察氯胺酮对体外循环病人IL 6和IL 8含量的影响并探讨其临床意义。方法 :2 4例择期瓣膜替换术病人分成氯胺酮组和对照组 ,每组 12例。氯胺酮组手术和转流开始按 1mg·kg-1静脉注射氯胺酮 ;对照组则采用等量生理盐水注射。测定手术病人不同时间血浆IL 6和IL 8含量明显低于对照组 (P <0 0 5 )。结论 :氯胺酮抑制体外循环病人IL 6和IL 8反应 。

Objective To investigate the effects of ketamine on cardiopulmonary bypass induced IL 6 and IL 8 response. Methods Twenty four adult parients undergoing cardiac valve replacement were divided into control and ketamine group (n=12). In the ketamine group, 1 mg·kg -1 ketamine was infused intravenously at the beginning of operation and CBP. Plasma levenof IL 6 and IL 8 were measured at different time after induction of anesthesia. Results In both groups, the levels of IL 6 and IL 8 increased significantly compared with those at the time before CBP (P<0 05), but compared with those in control groups, IL 6 and IL 8 levels decreased obviously in ketamine group(P<0 05). Conclusions Ketamine is effective to reduce cardipulmonary bypass induces IL 6 and IL 8 response and protect reperfusion myocardium.