苄青霉素钠盐结晶热力学分析

Study on the crystallization thermodynamics of sodium benzylpenicillin

采用扫描电子显微镜考察了苄青霉素钠盐的晶体形态变化情况 ,利用泡点法计算得到含有苄青霉素钠盐的混合溶剂的汽液平衡数据 ,采用激光法测定了苄青霉素钠盐在混合溶剂体系中的结晶介稳区数据 ,建立了苄青霉素钠盐的混合溶剂体系在结晶过程中的汽 -液

The variation of crystal habit of sodium benzylpenicillin (GNa) was studied by scanning electron microscope. The data of the Vapor liquid equilibrium solvent mixture were calculated by the bubbling point method and the data of the metastable zone for GNa in the solvent mixture were determined by a laser method. Finally, a vapor liquid solid equilibrium diagram for the crystallization experiment was established.