子宫肌瘤和正常子宫肌层中bcl-2蛋白的表达

Expression of bcl-2 protein in uterine leiomyomas and normal myometrium

目的 :研究凋亡调节蛋白 bcl 2 在子宫肌瘤和正常子宫平滑肌中的表达。方法 :用免疫组织化学ABC法检测 40例子宫肌瘤组织和正常子宫平滑肌组织中的bcl 2蛋白的表达。结果 :bcl 2在肌瘤组织中的表达强于正常子宫平滑肌组织 ,且分泌期强于增生期 (P <0 .0 1)。结论 :凋亡抑制基因bcl 2增加可能在子宫肌瘤的肿瘤发生过程中起一定作用。这种作用可能受到孕激素的调节。

Objective To study the expression of the apoptosis regulatory protein bcl 2 in the uterine leiomyomas and in the normal myometrium. Methods The expression of bcl 2 protein was examined by immunohistochemical ABC staining in 40 cases of uterine leiomyomas and normal myometrium. Results bcl 2 expression was higher in the uterine leiomyomas than that in the normal myometrium, both in the proliferative phase and in the secretory phase of the menstrual cycle (P<0.01); bcl 2 expression in leiomyomas in the secretory phase was stronger than that in the proliferative phase of the menstrual cycle (P<0.01). Conclusions The increase of apoptosis inhabiting gene bcl 2 may play an important role in the growth of the uterine leiomyomas. This action may be regulated by progesterone.