抗生素糊剂诱导年轻恒牙根尖形成的实验研究

INVESTIGATION OF USING ANTIBIOTICS TO INDUCE APEXIFICATION

目的 :观察抗生素糊剂控制根管内感染 ,诱导年轻恒牙根尖形成的作用 ,以证实其组织学效果并阐述牙根继续发育的可能机理。 方法 :实验采用组织学方法 ,选用未成年家犬 ,牙齿去髓后 ,将抗生素糊剂分别填入动物未经根管和开放和经根管开放的根管内 ,术后 4、 8、 12周处死动物 ,常规组织学制片 ,镜下观察牙根尖的组织形态变化。 结果 :抗生素在控制感染 ,消除尖周病变的同时 ,两组根尖端均发现有骨样牙本质和骨样牙骨质结构的硬组织沉积 ,使根尖继续发育 ,封闭根端。 结论 :抗生素糊剂在诱导根尖形成中的作用并非它本身的直接诱导 ,而在于它控制根管内感染 。

Objective:The authors observed the use of antibiotics which(be in root canals)controled the infection in the root canals on root growth of immature teeth,and evaluated the effect of controlling the infection in the root canals on root formation by using antibiotics. Methods:Young dogs with immature teeth were used,and the root canals of experimental animals were filled with antibiotics.Animals were sacrificed after 4,8,12 weeks respectively,then sections were prepared routinely and observed the histomorphological findings with microscope. Results:In the antibiotics treatment roots,periapical inflammation disappeared and hard tissues as osteoid dentin and osteoid comentum deposited on the apices,the root continued to form and close. Conclusion:The effect of antibiotics in inducing the formation of apices is to prevent infection of root canal,rather than direct induction