体外循环转流期间红细胞膜流动性的变化

Change of Erythrocyte Membrane Fluidity during Cardiopulmomary Bypass

对 2 5例心脏手术行体外循环患者转流期间红细胞膜流动性 (fluidity ,FLU)、血浆脂质过氧化物 (LPO)和红细胞超氧化物岐化酶 (SOD)动态变化进行观察 ,结果转流后期FLU显著降低 ,LPO显著升高 ,而SOD活性转流初期升高明显 ,至转流后 2 4小时恢复到转流前水平 ,并且红细胞膜FLU降低血浆LPO改变呈负相关 .提示 :转流期间脂质过氧化增强 ,可能是红细胞膜流动性降低的原因之一 .

Changes of erythrocyte membrane fluidity(FLU) and plasma lipid peroxidation (LPO) and SOD in erythrocyte were observed in 25 patients undergoing heart operations during cardiopulmonary bypass (CPB) and after CPB.The results indicate: the LPO was significantly increased and the FLU was greatly decreased at 60 min after the start of CPB. During CPB the activity SOD in erythrocyte was significantly increased, at 24 h the end of CPB, the activity returned to the level before CPB. The decrease of FLU was correlated negatively with the level of LPO. This suggests that the increase of LPO might be one of the causes of the decrease of FLU in patients undergoing CPB and after CPB.