盐酸维拉帕米脉冲释放片家犬体内的药动学及生物利用度

Study on pharmacokinetics and bioavailability of verapamil hydrochloride pulsed-release tablets in dogs

目的：比较盐酸维拉帕米脉冲释放片与其片芯在家犬体内的药动学特征及生物利 用度。方法：采用拉丁方设计，将家犬6只随机分为2组，交叉口服IV型脉冲片和片芯，以片芯为对 照制剂，考察体内脉冲效果。结果：IV型脉冲片在家犬体内的时滞为4 h，而Cmax、AUC等无明显差异，达到设计要求 。结论：本研究制备的脉冲释放制剂为防治心血管疾病的凌晨发作提供了一个良好的剂型选择 。

OBJECTIVE To compare the pharmacokinetics and bioavailability of verapamil hydrochloride p ulsed release tablets with core tablets. METHODS Latin test was employed in the single oral administration of the IV pulsed rele ase tablets and core tablets with 6 dogs.The in vivo pharmaceutics behavior of t he tablet had been evaluated by the lag time and C max, AUC et al. RESULTS The pharmacokinetics results demonstrated that the IVpulsed tablet in humans co uld be released after about 4 h lag time.In the proper range, C max,AUC were not different with core tablets. CONCLUSIONS A new system useful to reduce the early morning symptoms of ischemic heart disea se was prepared.