侧侧缝合法治疗不完全性周围神经损伤的实验研究

An Experimental Study of the Side-to-side Neurorrhaphy to Repair Incomplete Injury of Peripheral Nerve

目的 :提出一种新的治疗不完全性周围神经损伤的方法—侧侧缝合法 ,并对其疗效进行初步的实验研究。方法 :SD大鼠 12只 ,双下肢随机分为实验侧和对照侧。将两侧腓总神经在相同部位以相同的力度钳夹损伤 ;实验侧将损伤的腓总神经远端与胫神经靠拢后 ,切开相邻面的束、外膜 ,互相侧侧缝合 ,对照侧不作进一步处理。 3个月后 ,对神经的再生情况进行肌电图、组织学等检测。结果 :实验侧腓总神经远端有良好的神经再生 ,再生的神经纤维质量与对照侧相比有显著差异 (P <0 .0 5 )。结论 :不完全性周围神经损伤经侧侧缝合修复 ,可以获得较好的再生 ;

Objective: To describe a new method of side to side neurorrhaphy for the repair of peripheral nerve incomplete injury and study the effect after this procedure.Methods:12 SD rats were used;bilateral lower extremities of the animals as the operated specimens were randomly divided into experimental and control sides.The peroneal nerve of two side were clipped with identical strength,in experimental side,the distal segment was kept close to neighboring tibial nerve,and then the epineurium and perineurium of two neighboring segment were incised,at last,two nerve were anastomosed by side to side neurorrhaphy.The nerve regeneration was analyzed with electromyographic and histological examination after 3 months.Results:A large number of nerve fibers were found in the distal peroneal nerve of experimental side,the quality of the regenerated fibers exhibited significant difference from control side( P <0.01).Conclusion:The side to side neurorrhaphy was a new valuable method to repair incomplete injury of peripheral nerve.