糖尿病糖化血红蛋白监测的临床意义

Significance of glycosylated Hemoglobin in Diabetic Mellitus

本文测定65例糖化血红蛋白、空腹血糖正常参考值 GHb6.34±S1.21%;FPG4.98±S0.88mmol/L,两者呈正相关,相关系数 r0.511,P<0.01。185例糖尿病病人GHb9.95±S2.90%;FPG10.96±S5.07 mmol/L,两者相关系数 r0.7225 P<0.01。将正常人组、糖尿病组、糖尿病控制较差组、控制较好组进行统计分析,各组之间的 GHb、FPG 都有显著性差异 P<0.01。GHb 监测是观察糖尿病疗效、病情控制好否一个有效指标。连续随诊的两例糖尿病患者 GHb、FPG 监测结果看出病情控制好否、GHb,FPG 含量高低与合并症发生有一定关系。

To evaluate the significance of glycosylated hemoglobin(GHb)in diabetic mellitus,the correlation between fasting plasma glucose(FPG) and GHb was analyzed in 65 normal volunters and 185 diabetic patients. Our results showed the GHb was positively association with FPG in normal group(GHb=6.34±S1.21% and FPG=4.98±S0.88 mmol/L)and in diabetic group(GHb=9.95+S2.90% and FPG=10.96±S5.07 mmol/L), Correlation index was 0.511 and 0.722(P<0.01).There were significant difference in GHb and in FPG among normal group,Well controlled diabetic group and poor controlled group(p<0.01).Our results Suggests that GHb is a efficient index to assess Curative effect of diabetic mellitus. The relation-ship between level of GHb and chronic complication of diabetic mellitus was discussed.