原发性慢性肾小球肾炎患者血清CⅣ,LN,PCⅢ的变化及意义

Clinical Sigificance of Serum Type Ⅳ Collagen, Type Ⅲ Procollagen and Laminin in Patients with Chronic Glomerulonephritis

目的 探讨原发性慢性肾小球肾炎 (CGN)患者血清Ⅳ型胶原 (CⅣ )、Ⅲ型前胶原 (PCⅢ )、层粘连蛋白 (LN )的变化及意义及与肾脏病理的关系。方法 用放免法对 78例CGN患者及 34例正常人血清CⅣ ,PCⅢ ,LN水平进行检测 ,对其中的 32例系膜增生性肾炎 (MSPG)三者水平进行分析。结果 CGN患者血清CⅣ ,PCⅢ ,LN水平显著高于正常人(P分别为 0 .0 1,0 .0 1,0 .0 5 ) ,患者血清三者水平升高程度与MSPG肾病理改变的严重程度显著相关。结论 CGN患者存在胶原代谢的紊乱 ,血清CⅣ ,PCⅢ ,LN水平随肾脏病理改变的严重程度而升高 ,血清三者水平对CGN患者的诊断有帮助 ,部分反映患者肾病理改变严重程度。

Objective To explore the possible relationship among serum type Ⅳ collagen (CⅣ), type Ⅲ procollagen (PCⅢ) and Laminin (LN) with chronic glomerulonephritis (CGN) patients and their renal pathological change and renal function. Methods Serum CⅣ, PCⅢ and LN were determined by radioimmunoassay in 78 CGN patients, 34 normal subjects as control, and 32 case of mesangial proloferative glomerulonephritis (MSPG) were studied. Results Serum CⅣ, PCⅢ and LN were higher than normal ( P<0.01, P<0.01, P<0.05 ), and there were significant positive correlation with the severity of renal pathological injury in MSPG. Conclusion Abnormal collagen metabolism exists in CGN patients. The increased serum CⅣ, PCⅢ and LN levels in MSPG are related to the severity of renal pathological injury and could be an sensitive marker of CGN.