胃粘膜黄色瘤30例病理分析

Pathological Analysis of the Gastric Murcosa Xanthoma in 30 Cases

目的 探讨 30例胃粘膜黄色瘤的发病原因、病理形态学改变及临床意义。方法 运用病理组织学、组化病理学 ,结合临床研究本病的诊断及鉴别诊断。结果 男多于女性 ,为 5∶1,平均年龄 5 6 2 0岁 ,45岁以上占 87% ;多发于胃窦部 ,占 87% ;11例生化检查 :5例TG、3例ch均高出正常标准 ;胃镜见隆起的小斑块 ,光镜见局灶性泡沫状细胞 ,PAS染色呈阴性。结论 胃黄色瘤属瘤样病变 ,是慢性胃炎引起的胃粘膜破坏 ,并由吞噬细胞吞噬含脂质物质聚集而成的泡沫状结构 ;病因与肠上皮化生、中老年肥胖、高血脂症及HP感染有密切关系。

Objective To research the cause, the pathomorphism change and its clinical significance in 30 gastric murcosa xanthoma cases. Methods The diagnosis and differential diagnosis of this disease were studid using the histopathological and pathological chemistry methods. Results We find that male-patients were more than the female(5∶1), their average age was 56.20 year and the percent of over 45 years is 86.66% in this disease. The more happened sections were found in gastric antrum(86.67%). The plasma triglyceride (5 cases) and cholesterol(3 cases)were higher than normal in 11 cases. Foeal foam cells were found in gastroscope. PAS colored negativly. Conclusion Gastric xanthoma, a kind of neoplastic hyperplasia, is one foam structure of phyagocgfolysis after swallowing liposome, which is caused by chronical gastritis, and leads spoiled gastric murcosa. The cause of xanthome is related to intestinal metaplasia fat in middle and old age, hyperlipoidemia and HP infection.