原发性肝癌治疗前后血清可溶性上皮钙粘蛋白水平变化的研究

The Changes of Serum SE-Cadherin Levels Before and After Treatment in Cases of Hepatocarcinoma

目的 :探讨原发性肝癌 (HCC)患者治疗前、后的血清可溶性上皮钙粘蛋白 (SE- Cadherin)水平变化。方法 :用酶联免疫吸附双抗体夹心法检测 2 6例 HCC患者治疗前、后的血清 SE- Cadherin水平及 2 1例正常健康人血清 SE- Cad-herin水平。结果 :原发性肝癌患者治疗前血清 SE- Cadherin水平明显高于治疗后 ,其差异有显著性意义 (P<0 .0 1)。而正常健康人血清 SE- Cadherin水平不高。结论 :血清 SE- Cadherin水平的测定可作为原发性肝癌的诊断及疗效观察指标 ,并有可能成为预后评判和复发指标。

Objective:To study the changes of serum SE Cadherin levels before and after treatment in patients with hepatocarcinoma.Methods:The serum SE Cadherin levels were measured in 26 patients with hepatocarcinoma and 21 normal subjects by the enzyme immunosorbent double antibody technique.Results:Before the treatment,the patients with hepatocarcinoma showed a higher serum SE cadherin level as compared to that after the treatment( P <0.01).The serum SE Cadherin level in control group was not high.Conclusion:The serum SE Cadherin level may be an indicator for diagnosis of, and treatment effect in hepatocarcinoma