摘要
上皮型钙粘蛋白是重要的细胞粘附分子和传导分子 ,它在组织形态发生、胚胎发育和细胞凋亡等过程中均起重要作用。作为细胞间粘附分子上皮型钙粘蛋白是通过控制细胞转移来实现其功能的。最近的研究提示 :肿瘤的发生和发展与上皮型钙粘蛋白的功能失调有关 ,而且 ,临床上血清可溶性上皮型钙粘蛋白与肿瘤的分级及预后有一定的相关关系。本文就这种新的标志物与肿瘤的诊断、治疗及预后的关系研究进展进行综述。
Epithelial cadherin is an important cell adhesion molecule and cell signal transduction molecule,it plays an important role in tissue morphologic formation,embryogeny and development as well as cell fate.E cadherin as a cell adhesion molecule is fulfilled by controlling cell migration.Recent research revealed that tumoriginesis and development was related to E cadherin malfunction.More recent research revealed that there was an relationship between serum soluble E cadherin and tumor prognosis.This article reviews the advance of study on E cadherin in tumor diagnosis,therapeutic effect and prognostic estimation.
出处
《华夏医学》
2001年第4期552-554,共3页
Acta Medicinae Sinica
关键词
钙粘蛋白
肿瘤
标志物
血清
诊断
治疗
预后
epithelial cadherin
cell adhesion molecule
signal transduction
tumor
