不稳定型心绞痛CD63、CD62P、C-RP的变化及灯盏花的影响

Effect of Dengzhanhua on platelet activating factors CD63 and CD62P and C-RP in patients with unstable angina pectoris

目的 :观察血小板表面活性蛋白即血小板颗粒膜蛋白 (CD6 3)、溶酶体膜蛋白 (CD6 2 P)及血浆 C-反应蛋白(C- RP)在不稳定型心绞痛 (U AP)发生、发展中的作用及灯盏花的影响。方法 :5 9例 U AP患者随机分成灯盏花组(32例 )及抵克力得组 (2 7例 ) ,并对照观察治疗 8周前、后血小板 CD6 3、CD6 2 P及血浆 C- RP水平的变化。结果 :(1)与健康人及稳定性心绞痛 (SAP)对照组比较 ,UAP患者血小板 CD6 3、 CD6 2 P及血浆 C- RP水平明显升高 (P<0 .0 5 ,P<0 .0 1) ;(2 )治疗 8周后 ,灯盏花及抵克力得组 CD6 3、CD6 2 P及血浆 C- RP测定值分别显著低于治疗前水平 (P<0 .0 5 ,P<0 .0 1) ,且两组上述各指标水平差异无显著性。结论 :血小板活化及炎症反应物在 UAP发生及发展过程中起着重要的作用 。

Objective:To explore the action of platelet surface activity protein(platelet granule membrane protein CD63 and lysosome membrane protein CD62P) and C\|reactive protein(C\|RP) in occurrence and development of unstable angina pectoris(UAP),and the effect of Dengzhanhua on them. Methods:Patients with UAP were randomly divided into the treated group(32 cases,treated with Dengzhanhua) and the control group(27 cases,treated with ticlid),the therapeutic course was 8 weeks for both groups.Changes of CD63,CD62P and C\|RP before and after treatment were observed.Results:The levels of CD63,CD62P and C\|RP were higher in UAP patients than those in normal subjects and patients with stable angina pectoris( P <0 05, P <0 01),after 8\|week treatment the above\|mentioned parameters lowered in both groups( P <0 05, P <0 01),and comparison between the two groups showed no significant difference statistically.Conclusion:Platelet activation and C\|RP play an important role in the occurrence and development of UAP.The obvious effect of Dengzhanhua in anti\|platelet activation and relieving inflammatory reaction is of great importance in preventing the occurrence and development of acute coronary syndrome clinically.