安痔注射液及消痔灵应用后的病理观察

Pathological examination of piles treated with Anzhi Injection and Xiaozhiling

目的 :对痔内注射安痔注射液及消痔灵后的组织病理学变化进行观察与比较。方法 :35例内痔混合痔患者中 ,注射安痔注射液治疗 2 5例、注射消痔灵治疗 10例。分别于治疗后的不同时间取活检标本 ,做病理组织学观察。结果 :注射安痔注射液后引起组织发生一种非炎症性的蛋白凝固样变性 ,血管收缩闭合 ,此变性可逆 ,容易“复活” ,经过 3d～ 7d ,可原位修复 ,无瘢痕形成 ,其间不发生明显的炎症、出血、坏死等改变。消痔灵注射后引起的是一种无菌性炎症 ,组织内出现明显水肿、出血、炎症反应 ,扩张静脉内血栓形成以及有瘢痕形成。结论 :消痔灵引起的水肿、出血及炎症反应等改变均明显重于安痔注射液 ,7d后的血栓机化、内皮细胞生长不如安痔注射液活跃 ,且在组织中引起瘢痕形成。

Objective:To find out the pathologic changes of piles treated with Anzhi Injection and Xiaozhiling and evaluate effectiveness of these injections. Methods:Biopsies of piles were taken from 25 cases of Anzhi Injection and 10 cases of Xiaozhiling at different times after injections.Results:In the early period after Anzhi Injection , tissues showed protein coagulation degeneration in which vessels contracted or disappeared.This kind of degeneration was reversible.Tissues got revived in 3 to 7 days.There were no obvious inflammation,hemorrhage and necrosis during this period.And there was no scar formation.Tissues that injected with Xiaozhiling showed asepsis inflammation,obvious edema,hemorrhage and inflammation reactions.In addition,there were thrombosis in expanded veins and scars in tissues.Conclusion:Edema,hemorrhage and inflammation of Xiaozhiling group were much obvious than those of Anzhi group.7 days after injection,organization of thrombus and regeneration of epithelium in Xiaozhiling group were not so active as those in Anzhi group.Moreover,there was scar formation in Xiaozhiling group.