喉癌喉部分切除术的术后分析

Clinical retrospective analysis of treating laryngeal cancer by partial laryngectomy and the immunohistochemical study of cut edge of laryn-geal cancer

目的 分析喉癌喉部分切除术后复发的原因和对部分喉切除术的回顾分析。方法 用免疫组化的方法分析部分喉切除术后肿瘤切缘组织PCNA表达和9例肿瘤复发的关系及7例喉部分切除术后治疗效果的回顾分析。结果 在77例部分喉切除病例中,13例在术后2周拔管,11例3个月拔管,41例1个月拔管,1例6个月拔管,11例未能拔管。3年、5年生存率分别为94％、81％。共9例复发,其中3例做了全喉切除术。结论 如适应症掌握恰当,肿瘤切除足够,部分喉切除治疗喉癌是安全有效的。肿瘤切缘保留组织中PCNA阳性可为防止肿瘤复发提供较敏感依据。

Objective To analyse the cause of recurrence of laryngeal cancer after partial laryngectomy. Methods ABC method of immu-nohistochemical method was used to test 77 samples from cutting edge of laryngeal cancer with partial laryngectomy. Results Among the 77 cases of partial laryngectomy (37% ) from the 210 total laryngectomy admitted, 13 cases were extubated two weeks after operation, 41 cases extuated in a month, 11 cases extuated 3 months and 11 cases could not be extuated after operation. The rates: 3-year-survival rate was 94% , 5-year-survival rate 81 % . There were 9 cases recurred (17%), 3 of them were total laryngectomy. Conclusion If suitable cases are selected, treatment of laryngeal cancer by partial laryngectomy should be efiective. The positive result of PCNA in the tissue of cutting edge is a sensitive evidence for preventing recurrence .