心肌缺血动物模型经皮激光血运重建术后心肌灌注与病理结果分析

A Machanism Study of PMR Procedure by ^(99m)Tc-MIBI SPECT and Pathology in the Myocardial Ischemia Animals

目的 阐明经皮激光心肌血运重建术可能的治疗机制。方法 杂种健康犬 40只 ,建立心肌缺血动物模型 ;L组送入导管室 ,进行标准前降支部位PMR操作 ,C组对照 ;两组分别于SPECT心肌灌注扫描后处死 ,取心肌组织制作病理标本。结果 PMR后L组改善率 6 8.3% ,明显高于C组 ,未改善率和变坏率明显低于C组 ;病理组织切片显示激光孔道通畅率各时间点分别为 89% ,5 3% ,42 % ,34 %和 2 5 %。

Objective To investigate the machanism of PMR percedure.Methods After fourty mongrel dogs underwent thoracotomy, myocardial ischemia animal models had been established. The laser catheler was inserted into LV via a guider and myocardial channels were completed in the L group. Before and after PMR procedure, 99m Tc MIBI SPECT and pathologic slice were compared. Results There were improvement of 68.3% in the myocardial perfusion after PMR in the L group. Laser channels of 89%, 53%, 42%, 34%, 25% were opened.Conclusion The machanism of PMR procedure is very complicated, and it include many facters.