α-氨基膦酸酯和氨基膦酸的合成及其抗菌活性

Synthesis and Fungicidal Activity of Chiral α-amino Phosphoric Acid and Their Esters

合成了 1个手性希夫碱 ,探讨了它们与亚磷酸酯的不对称加成 ,手性希夫碱的立体选择性加成反应的影响如下 :Me <Et <n Pr<i Pr,即R的体积效应与立体选择性相一致。合成并分离出了 4个新手性 (+) α (3 莰 2′ 基脲基 )氨基卤苄基膦酸二烃基酯 ,它们的结构均经过IR、3 1PNMR、1H NMR及其元素分析等证明 ,并初步探讨了它们的光谱规律。最终合成了 1个氨基膦酸 ,并成功的回收了手性源———莰胺。

One chiral Schiff base was synthesized via a condensed reaction.Asymmetric addition of these Schiff bases and phosphorous esters was discussed.Cubic effects in the reaction as follows:Me<Et<n Pr<i Pr.Four O,O dialkyl( N ′ camph 2 ylreido)benzyl phosphoric esters were prepared.Their structures were confirmed by IR? 31 PNMR? 1H NMR and elemental analysis.This procedure offered the good method for novel chiral amino phosphoric acids.This method is convenient,simple,good yield for preparation of α amino phosphoric acids and at the same time the chiral inductor was recollected.