一氧化氮合成酶抑制剂的研究进展

Recent Advances in the Study on Inhibitors of Nitric Oxide Synthase

一氧化氮 (NO)具有广泛的生理功能。哺乳动物体内的NO是由NO合成酶 (NOS)氧化L 精氨酸而合成的 ,合成后的NO迅速跨膜扩散释放。NO合成失调能介导多种疾病产生。特异性NOS抑制剂能通过调控NO的合成 ,对NOS表达相关的各种疾病的防治具有重要的临床意义。

Nitric Oxide (NO) plays various roles in a number of physiological and pathological processes.It was generated from L arginine by the family enzymes known as nitric oxide synthase (NOS).Synthetic NO was rapidly released across transmenbrane diffusion.Dysfunction of NO formation has been implicated in various diseases.The specific inhibitors of NOS may be useful in the prevention/therapy of a variety of diseases associated with induction of NOS.This article surveyed the recent advances on the study of NOS inhibitors.